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J Vasc Interv Radiol. 2009 Jan;20(1):113-7. doi: 10.1016/j.jvir.2008.09.033. Epub 2008 Nov 22.

Considerations for implantation site of VX2 carcinoma into rabbit liver.

Author information

1
Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Abstract

PURPOSE:

To assess whether the implantation site of VX2 carcinoma into rabbit liver affects successful vessel selection for transcatheter arterial interventions.

MATERIALS AND METHODS:

Twenty-four New Zealand White rabbits were randomly assigned to two groups. All implantations were performed by open laparotomy with minced tumor cells inserted into a 16-gauge Angiocath needle. Group I rabbits (n = 12) had tumor implanted into the left medial lobe of the liver and group II rabbits (n = 12) had tumor implanted into the left lateral lobe. Two weeks after implantation, selective angiography was performed for subsequent chemoembolization, which was part of a different study. Tested variables included maximum tumor diameter, tumor feeding artery size, and tumor vascularity.

RESULTS:

Successful tumor growth was achieved in all rabbits. Selective angiography was possible in 33.3% of rabbits in group I and 66.6% of rabbits in group II (P < .05). Tumor size and vascularity were similar between groups. Mean lengths of tumor feeder arteries from the bifurcation of the left hepatic artery were 4.1 mm +/- 1.2 in group I (left medial lobe) and 10.8 mm +/- 3.0 in group II (left lateral lobe; P < .05). The angulation of the left medial lobar artery (group I) off the left hepatic artery was acute in eight of 12 rabbits (66.6%), but only four of 12 rabbits in group II (33.3%) showed acute angulation of the left lateral lobar artery off the left hepatic artery (P < .05). Mean angiography time was significantly shorter in group II.

CONCLUSIONS:

For selective hepatic arterial interventions, the left lateral lobe of the liver may be favorable as an implantation site for VX2 tumors in rabbits.

PMID:
19028118
PMCID:
PMC2747297
DOI:
10.1016/j.jvir.2008.09.033
[Indexed for MEDLINE]
Free PMC Article
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