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Breast. 2010 Oct;19(5):417-23. doi: 10.1016/j.breast.2010.04.005. Epub 2010 May 8.

Urban-rural differences in breast cancer incidence in Egypt (1999-2006).

Author information

1
Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory Street, Ann Arbor, MI 48109, USA. subhojit@umich.edu

Abstract

OBJECTIVE:

To describe urban-rural differences in breast cancer incidence in Gharbiah, Egypt and to investigate if these differences could be explained by known risk factors of breast cancer.

METHODS:

We used data from the population-based cancer registry of Gharbiah, Egypt to assess breast cancer incidence from 1999 through 2006. The Egyptian census provided data on district-specific population, age, and urban-rural classification. Incidence patterns of breast cancer by district and age-specific urban-rural differences were analyzed.

RESULTS:

Overall, incidence rate of breast cancer was three to four times higher in urban areas than in rural areas (60.9/10(5)-year for urban areas versus 17.8/10(5)-year for rural areas; IRR=3.73, 95% CI=3.30, 4.22). Urban areas had consistently higher incidence of breast cancer across all age-groups for all years. Higher incidence of breast cancer was also seen in the more developed districts of Tanta and El-Mehalla.

CONCLUSIONS:

Higher incidence of breast cancer in urban and more developed populations might be related to higher exposure to xenoestrogens, as well as other endocrine disruptors and genotoxic substances.

PMID:
20452771
PMCID:
PMC3209663
DOI:
10.1016/j.breast.2010.04.005
[Indexed for MEDLINE]
Free PMC Article

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