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Br J Psychiatry. 2008 Nov;193(5):424-5. doi: 10.1192/bjp.bp.107.040501.

Time course of regional brain activation associated with onset of auditory/verbal hallucinations.

Author information

1
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA. ralph.hoffman@yale.edu

Abstract

The time course of brain activation prior to onset of auditory/verbal hallucinations was characterised using functional magnetic resonance imaging in six dextral patients with schizophrenia. Composite maps of pre-hallucination periods revealed activation in the left anterior insula and in the right middle temporal gyrus, partially replicating two previous case reports, as well as deactivation in the anterior cingulate and parahippocampal gyri. These findings may reflect brain events that trigger or increase vulnerability to auditory/verbal hallucinations.

PMID:
18978327
PMCID:
PMC2801815
DOI:
10.1192/bjp.bp.107.040501
[Indexed for MEDLINE]
Free PMC Article

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