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J Am Chem Soc. 2008 Oct 22;130(42):13854-5. doi: 10.1021/ja805775u. Epub 2008 Sep 26.

Polymeric PARACEST agents for enhancing MRI contrast sensitivity.

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1
Department of Chemistry, University of Texas at Dallas, P.O. Box 830668, Richardson, Texas 75083, USA.

Abstract

Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.

PMID:
18817395
PMCID:
PMC2723842
DOI:
10.1021/ja805775u
[Indexed for MEDLINE]
Free PMC Article
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