Send to

Choose Destination
See comment in PubMed Commons below
Curr Biol. 2008 Sep 9;18(17):R777-R783. doi: 10.1016/j.cub.2008.07.035.

Coordinating speed and amplitude in G-protein signaling.

Author information

  • 1Department of Pharmacology, Graduate Programs in Molecular Biophysics and Cell Regulation, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390-9041, USA.

Erratum in

  • Curr Biol. 2008 Dec 9;18(23):1896.


G-protein-mediated signaling is intrinsically kinetic. Signal output at steady state is a balance of the rates of GTP binding, which causes activation, and of GTP hydrolysis, which terminates activation. This GTPase catalytic cycle is regulated by receptors, which accelerate GTP binding, and GTPase-activating proteins (GAPs), which accelerate hydrolysis. Receptors and GAPs similarly control the rates of signal initiation and termination. To allow independent control of signal amplitude and of the rates of turning the signal on and off, the activities of receptors and GAPs must be coordinated. Here, the principles of such coordination and the mechanisms by which it is achieved are discussed.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center