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Proc Am Thorac Soc. 2008 Sep 15;5(7):783-91. doi: 10.1513/pats.200803-027HR.

Lung vascular cell heterogeneity: endothelium, smooth muscle, and fibroblasts.

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1
Center for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA. tstevens@jaguar1.usouthal.edu

Abstract

The pulmonary circulation represents a unique vascular bed, receiving 100% of the cardiac output while maintaining low blood pressure. Multiple different cell types, including endothelium, smooth muscle, and fibroblasts, contribute to normal vascular function, and to the vascular response to injury. Our understanding of the basic cell biology of these various cell types, and the roles they play in vascular homeostasis and disease, remains quite limited despite several decades of study. Recent advances in approaches that enable the mapping of cell origin and the study of the molecular basis of structure and function have resulted in a rapid accumulation of new information that is essential to vascular biology. A recent National Institutes of Health workshop was held to discuss emerging concepts in lung vascular biology. The findings of this workshop are summarized in this article.

PMID:
18757318
PMCID:
PMC2645266
DOI:
10.1513/pats.200803-027HR
[Indexed for MEDLINE]
Free PMC Article
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