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Eur J Immunol. 2008 Apr;38(4):921-4. doi: 10.1002/eji.200738104.

Human regulatory T cells and autoimmunity.

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1
Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.

Abstract

CD4+CD25+ regulatory T cells (Treg) appear to be critical in regulating immune responses to self-antigens. Treg deficiency is associated with several human autoimmune diseases. Although substantial progress has been made in the study of murine and human Treg, their fundamental mechanism of action remains unknown. In this review, we discuss the phenotype of human natural Treg, their functional mechanism, and their role in autoimmune disease.

PMID:
18395861
PMCID:
PMC2752283
DOI:
10.1002/eji.200738104
[Indexed for MEDLINE]
Free PMC Article
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