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Bioconjug Chem. 2008 Feb;19(2):418-20. doi: 10.1021/bc700451b. Epub 2008 Jan 11.

Lipophilic peptides for gene delivery.

Author information

1
Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.

Abstract

DNA transfections are widely performed in research laboratories and in vivo gene delivery holds the promise for curing many diseases. The synthetic carriers or vectors for DNA are typically cationic lipids. However, in biology, the recognition of nucleic acids by proteins involves both electrostatic and stacking contributions. As such we have prepared a series of new lipophilic peptide vectors that possess lysine and tryptophan amino acids for evaluation. These lipophilic peptides show minimal cytotoxicity and enhanced in vitro gene transfection activity.

PMID:
18186598
PMCID:
PMC2817964
DOI:
10.1021/bc700451b
[Indexed for MEDLINE]
Free PMC Article

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