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Cell Mol Life Sci. 2008 Jan;65(1):73-9.

Wound epidermis formation and function in urodele amphibian limb regeneration.

Author information

1
Department of Molecular, Cellular and Developmental Biology, Yale University, P. O. Box 208103, New Haven, CT 06520-8103, USA.

Abstract

Upon amputation of the urodele limb, the epidermal cells surrounding the amputation plane migrate to heal the wound. The resulting wound epidermis (WE) induces the regeneration process, resulting in blastema formation, cell division, and ultimately repatterning into a new limb. Despite its central role in the initiation of limb regeneration, little is known about how the WE forms. Here we discuss various models of WE formation and the experimental data in support of each.

PMID:
18030417
DOI:
10.1007/s00018-007-7433-z
[Indexed for MEDLINE]

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