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Pediatr Dev Pathol. 2008 May-Jun;11(3):239-44. Epub 2007 Jul 16.

Translocation (4;19)(q35;q13.1)-associated primitive round cell sarcoma: report of a case and review of the literature.

Author information

1
Department of Pathology, Children's Medical Center, and UT Southwestern Medical Center, Dallas, TX, USA. dinesh.rakheja@utsouthwestern.edu

Abstract

We report the 4th case of a primitive round cell sarcoma with the translocation (4;19)(q35;q13.1) as the primary cytogenetic abnormality. This undifferentiated sarcoma shows some features of Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), including a diffuse reactivity for FLI1, but it shows only focal and weak reactivity for CD99 and is negative for a rearrangement of EWS, the molecular signature of ES/PNET. Recognition of the histopathologic and cytogenetic features of this entity is necessary to avoid its misdiagnosis as ES/PNET, especially in small biopsy samples.

PMID:
17990934
DOI:
10.2350/07-06-0296.1
[Indexed for MEDLINE]
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