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J Neuroimmunol. 2007 Nov;191(1-2):70-8. Epub 2007 Oct 22.

Abnormal Tr1 differentiation in multiple sclerosis.

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1
Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. a.astier@ed.ac.uk

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). In the recent years, accumulating evidence has supported an immunosuppressive role for regulatory T cells (Tregs). Most studies in the context of autoimmunity have focused on the defects of the CD4+CD25 high Tregs. However, we recently demonstrated an altered function of Tr1 Treg cells in MS, characterized by a lack of IL-10 secretion. Therefore, several major regulatory T cell defects are involved in human autoimmune disease. Hence, the induction of Tregs or the stimulation of Treg activity may be beneficial for the treatment of such diseases.

PMID:
17936368
PMCID:
PMC2200628
DOI:
10.1016/j.jneuroim.2007.09.018
[Indexed for MEDLINE]
Free PMC Article
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