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PLoS Comput Biol. 2007 Jul;3(7):e118.

Not all scale-free networks are born equal: the role of the seed graph in PPI network evolution.

Author information

1
School of Computing Science, Simon Fraser University, Burnaby, British Columbia, Canada.

Abstract

The (asymptotic) degree distributions of the best-known "scale-free" network models are all similar and are independent of the seed graph used; hence, it has been tempting to assume that networks generated by these models are generally similar. In this paper, we observe that several key topological features of such networks depend heavily on the specific model and the seed graph used. Furthermore, we show that starting with the "right" seed graph (typically a dense subgraph of the protein-protein interaction network analyzed), the duplication model captures many topological features of publicly available protein-protein interaction networks very well.

PMID:
17616981
PMCID:
PMC1913096
DOI:
10.1371/journal.pcbi.0030118
[Indexed for MEDLINE]
Free PMC Article

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