Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2007 Aug 10;317(5839):819-23. Epub 2007 Jul 5.

High-speed imaging reveals neurophysiological links to behavior in an animal model of depression.

Author information

  • 1Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

Abstract

The hippocampus is one of several brain areas thought to play a central role in affective behaviors, but the underlying local network dynamics are not understood. We used quantitative voltage-sensitive dye imaging to probe hippocampal dynamics with millisecond resolution in brain slices after bidirectional modulation of affective state in rat models of depression. We found that a simple measure of real-time activity-stimulus-evoked percolation of activity through the dentate gyrus relative to the hippocampal output subfield-accounted for induced changes in animal behavior independent of the underlying mechanism of action of the treatments. Our results define a circuit-level neurophysiological endophenotype for affective behavior and suggest an approach to understanding circuit-level substrates underlying psychiatric disease symptoms.

PMID:
17615305
DOI:
10.1126/science.1144400
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center