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Dev Cell. 2007 Jul;13(1):4-6.

Ubiquitin ligation without a ligase.

Author information

1
Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA. mark.hochstrasser@yale.edu

Abstract

Classically, ubiquitination requires three enzymes acting in sequence: E1, E2, and E3. E3 ubiquitin ligases typically provide substrate specificity. An article in Molecular Cell (Hoeller et al., 2007) now describes the E3-independent monoubiquitination of certain proteins. The mechanism has interesting parallels to SUMO ligation.

PMID:
17609103
DOI:
10.1016/j.devcel.2007.06.003
[Indexed for MEDLINE]
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