Format

Send to

Choose Destination
See comment in PubMed Commons below
Brain Res Rev. 2007 Oct;55(2):204-19. Epub 2007 Mar 31.

The radial edifice of cortical architecture: from neuronal silhouettes to genetic engineering.

Author information

1
Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. pasko.rakic@yale.edu

Abstract

The developmental principles that establish the columnar edifice of the cerebral cortex underlie its evolution and dictate its physiological operations and cognitive capacity. This article contrasts the initial discoveries made by Ramón y Cajal and his contemporaries, based on the ingenious interpretation of neuronal shapes and their relationships using the Golgi method, with new insights based on the application of the most advanced methods of molecular biology and genetics. We can now propose a realistic model of how the sequence of gene expression, cascade of multiple molecular pathways and cell-cell interactions establish the number of neurons, guide their migration and allocation into proper regions and determine their differentiation into specific phenotypes that establish specific synaptic connections. The findings obtained from different levels of analyses sustain the radial unit hypothesis as a useful framework for understanding the mechanisms of cortical development and its evolution as an organ of thought.

PMID:
17467805
PMCID:
PMC2203611
DOI:
10.1016/j.brainresrev.2007.02.010
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center