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J Biol Chem. 2007 Jun 8;282(23):17061-8. Epub 2007 Apr 9.

Nucleoplasmic calcium is required for cell proliferation.

Author information

1
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8019, USA.

Abstract

Ca(2+) signals regulate cell proliferation, but the spatial and temporal specificity of these signals is unknown. Here we use selective buffers of nucleoplasmic or cytoplasmic Ca(2+) to determine that cell proliferation depends upon Ca(2+) signals within the nucleus rather than in the cytoplasm. Nuclear Ca(2+) signals stimulate cell growth rather than inhibit apoptosis and specifically permit cells to advance through early prophase. Selective buffering of nuclear but not cytoplasmic Ca(2+) signals also impairs growth of tumors in vivo. These findings reveal a major physiological and potential pathophysiological role for nucleoplasmic Ca(2+) signals and suggest that this information can be used to design novel therapeutic strategies to regulate conditions of abnormal cell growth.

PMID:
17420246
PMCID:
PMC2825877
DOI:
10.1074/jbc.M700490200
[Indexed for MEDLINE]
Free PMC Article

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