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Virology. 2007 Jun 20;363(1):113-23. Epub 2007 Feb 21.

Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II.

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  • 1Barbara Davis Center, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, Aurora CO, USA.


Virus-specific CD4(+) T cells contribute to effective virus control through a multiplicity of mechanisms including direct effector functions as well as "help" for B cell and CD8(+) T cell responses. Here, we have used the lymphocytic choriomeningitis virus (LCMV) system to assess the minimal constraints of a dominant antiviral CD4(+) T cell response. We report that the core epitope derived from the LCMV glycoprotein (GP) is 11 amino acids in length and provides optimal recognition by epitope-specific CD4(+) T cells. Surprisingly, this epitope is also recognized by LCMV-specific CD8(+) T cells and thus constitutes a unique viral determinant with dual MHC class I- and II-restriction.

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