Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Invest. 2007 Jan;117(1):83-6.

Prostaglandin-secreting cells: a portable first aid kit for tissue repair.

Author information

1
Howard Hughes Medical Institute (HHMI) and Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06405, USA.

Abstract

After intestinal injury, both the number and type of intestinal epithelial cells must be restored. Intestinal stem cells, located at the base of the intestinal crypt, repopulate the depleted crypt in a process known as compensatory proliferation. In this issue of the JCI, Brown et al. describe a new mechanism by which this process is regulated (see the related article beginning on page 258). Surprisingly, they find that a subset of stromal cells present within the intestinal tissue and expressing the proliferative factor prostaglandin-endoperoxidase synthase 2 (Ptgs2) is repositioned next to the intestinal stem cell compartment where local production of PGE(2) controls injury-induced epithelial cell proliferation.

PMID:
17200710
PMCID:
PMC1716222
DOI:
10.1172/JCI30865
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Society for Clinical Investigation Icon for PubMed Central
    Loading ...
    Support Center