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Small. 2006 Aug;2(8-9):1090-8.

Parallel manipulation of bifunctional DNA molecules on structured surfaces using kinesin-driven microtubules.

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1
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

Abstract

We have developed a technique to manipulate bifunctional DNA molecules: One end is thiolated to bind to a patterned gold surface and the other end is biotinylated to bind to a microtubule gliding over a kinesin-coated surface. We found that DNA molecules can be stretched and overstretched between the gold pads and the motile microtubules, and that they can form dynamic networks. This serves as a proof-of-principle that biological machineries can be used in vitro to accomplish the parallel formation of structured DNA templates that will have applications in biophysics and nanoelectronics.

PMID:
17193173
DOI:
10.1002/smll.200600112
[Indexed for MEDLINE]
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