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Org Lett. 2006 Nov 9;8(23):5385-8.

Efficient preparation of proline N-carboxyanhydride using polymer-supported bases.

Author information

1
Institute for Research in Biomedicine, Parc Científic de Barcelona IRB-PCB, Universitat de Barcelona, Josep Samitier 1-5, 08028 Barcelona, Spain.

Abstract

[Structure: see text] A procedure for the preparation of proline N-carboxyanhydride in high yield and purity is described using polymer-supported tertiary amines. The polymer-supported amine can be recycled with a basic wash and filtration of the resin. The procedure facilitates the access to the efficient preparation of the polyproline polymer with potential therapeutic interest.

PMID:
17078724
DOI:
10.1021/ol0622965
[Indexed for MEDLINE]
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