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Methods Mol Med. 2006;127:281-92.

The use of bone marrow-chimeric mice in elucidating immune mechanisms.

Author information

1
Section of Immunobiology, Yale University, New Haven, CT, USA.

Abstract

DNA vaccines hold promise for generating protective immunity against a wide variety of pathogens. Understanding the mechanism by which vaccine-encoded antigens are processed and presented to naïve lymphocytes in the host is critical for rational design of efficacious vaccines. This chapter provides practical guide in making irradiation-induced bone marrow chimeric mice, which can be used to dissect a variety of aspects of antigen presentation by the hematopoietic vs nonhematopoietic compartments.

PMID:
16988461
DOI:
10.1385/1-59745-168-1:281
[Indexed for MEDLINE]

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