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Biol Psychiatry. 2007 Jan 15;61(2):250-2. Epub 2006 Jul 24.

Antidepressant-like effects of ceftriaxone in male C57BL/6J mice.

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1
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06519, USA.

Abstract

BACKGROUND:

Excessive glutamatergic neurotransmission is hypothesized to be associated with depressive-like behaviors and possibly major depressive disorder (MDD). Recent evidence that beta-lactam antibiotic agents stimulate uptake of glutamate suggests that this class of compounds might possess antidepressant-like activity.

METHODS:

Three-month old, male, C57BL/6J mice were administered ceftriaxone (200 mg/kg IP) for 14-18 days, then tested in the tail-suspension, forced swim, and novelty-suppressed feeding tests to determine whether ceftriaxone had similar effects to classical antidepressant compounds in these models.

RESULTS:

Ceftriaxone treatment had an antidepressant-like effect across models. Reduced immobility and decreased freezing were observed in the forced swim and tail suspension tests. The same trend was seen in novelty-suppressed feeding, but the effect was not statistically significant.

CONCLUSION:

Ceftriaxone demonstrates antidepressant-like effects in several mouse models. This is consistent with the hypothesis that enhanced uptake of glutamate might have antidepressant-like effects.

PMID:
16860779
DOI:
10.1016/j.biopsych.2006.04.037
[Indexed for MEDLINE]
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