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World J Gastroenterol. 2006 Jun 14;12(22):3466-70.

Calcium signaling in cholangiocytes.

Author information

1
Department of Medicine Pharmacology, Yale University School of Medicine, 1 Gilbert Street, Room TAC S241D, New Haven, CT 06519, USA.

Abstract

Cytosolic Ca2+ is an important second messenger in virtually every type of cell. Moreover, Ca2+ generally regulates multiple activities within individual cells. This article reviews the cellular machinery that is responsible for Ca2+ signaling in cholangiocytes. In addition, two Ca2+-mediated events in cholangiocytes are discussed: bicarbonate secretion and apoptosis. Finally, emerging evidence is reviewed that Ca2+ signaling is involved in the pathogenesis of diseases affecting the biliary tree and that Ca2+ signaling pathways can be manipulated to therapeutic advantage in the treatment of cholestatic disorders.

PMID:
16773703
PMCID:
PMC4087562
DOI:
10.3748/wjg.v12.i22.3466
[Indexed for MEDLINE]
Free PMC Article

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