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J Physiol. 2006 Jul 1;574(Pt 1):33-9. Epub 2006 May 18.

The role of AMP-activated protein kinase in mitochondrial biogenesis.

Author information

1
Department of Inernal Medicine,Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, CT, USA.

Abstract

While it has been known for more than 75 years that physical activity is associated with increased mitochondrial content in muscle, the molecular mechanism for this adaptive process has only recently been elucidated. This brief review examines existing studies that have identified AMPK-activated protein kinase (AMPK) and several other key regulators of mitochondrial biogenesis, including peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta, calcium/calmodulin-dependent protein kinase IV, and nitric oxide. In addition, the potential role of mitochondrial dysfunction in the pathogenesis of insulin resistance associated with ageing and type 2 diabetes mellitus is also discussed.

PMID:
16709637
PMCID:
PMC1817787
DOI:
10.1113/jphysiol.2006.109512
[Indexed for MEDLINE]
Free PMC Article

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