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Nano Lett. 2006 Apr;6(4):815-9.

Microfluidic system for planar patch clamp electrode arrays.

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1
Department of Electrical Engineering, Yale University, New Haven, Connecticut 06520, USA.

Abstract

We present a microfluidic system integrated with disposable cell interface partitions for simultaneous patch clamp recordings. Glass-supported poly(dimethylsiloxane) (PDMS) partitions, having a 2 microm air-blown aperture, were reversibly sealed to a microfluidic system including PDMS channels with isolation valves and microfabricated Ag/AgCl electrodes. Gigaseal recordings from RBL-1 cells were obtained with a 24% success rate. Simultaneous whole cell recordings from valve-isolated electrodes were obtained.

PMID:
16608289
DOI:
10.1021/nl060165r
[Indexed for MEDLINE]
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