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J Pediatr Endocrinol Metab. 2006 Jan;19(1):31-8.

Congenital hypothyroidism and the second newborn metabolic screening in Colorado, USA.

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1
The Children's Hospital of Denver, Department of Endocrinology, University of Colorado Health Sciences Center, CO 80218, USA.

Abstract

OBJECTIVE:

To evaluate the effectiveness of a second newborn screening for congenital hypothyroidism (CH).

METHODS:

All infants born in Colorado, USA, from July 1996 through June 2004 had a total thyroxine measured with secondary thyroid stimulating hormone determination.

RESULTS:

The number of first and second newborn screens completed was 494,324 and 471,877, respectively. The first screen identified 185 cases of CH (incidence of 1:2,703). The second screen identified an additional 42 cases. Overall, the incidence based on both the first and second screenings was 1:2,174. The false negative rate for the first screen was 15.6%. In the absence of a second screen, one infant with CH out of every 11,111 babies screened would have been missed. The addition of the second screen increased the cost-per-case identified from dollars 6,108 to dollars 9,730.

CONCLUSIONS:

With only one newborn screen for CH, the number of missed cases is significant and higher than previously reported.

PMID:
16509526
[Indexed for MEDLINE]
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