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Dermatology. 2006;212(2):145-9.

Heredity: a prognostic factor for acne.

Author information

1
Department of Dermatology, Hôtel-Dieu, FR-44035 Nantes, France.

Abstract

BACKGROUND:

The role of heredity in acne severity and therapeutic response remains unclear.

OBJECTIVE:

A prospective epidemiologic study was performed to compare clinical and evolutive features of acne and response to treatment in 151 patients with acne with (A+) or without (A-) family history of acne.

METHODS:

A+ and A- patients were compared on clinical and therapeutic criteria. A+ patients were then distributed into subgroups (M+, F+, M+F+) following the origin of family history (father: F, mother: M).

RESULTS:

The clinical profile was similar in the A+ and A- populations. Acne occurred earlier and more often before puberty in the A+ population, in which oral treatments and relapse after isotretinoin were more frequent. Retentional lesions (number and extent) were more important in the M+ and M+F+ populations.

CONCLUSION:

This study confirms the importance of heredity as a prognostic factor for acne. Family history of acne is associated with earlier occurrence of acne, increased number of retentional lesions and therapeutic difficulties.

PMID:
16484821
DOI:
10.1159/000090655
[Indexed for MEDLINE]

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