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Physiology (Bethesda). 2006 Feb;21:13-8.

Cryo-EM and single particles.

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1
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA.

Abstract

Cryoelectronmicroscopy is a method for the imaging of macromolecules in the electron microscope. It was originally developed to determine membrane protein structures from two-dimensional crystals, but more recently "single-particle" techniques have become powerful and popular. Three-dimensional reconstructions are obtained from sets of single-particle images by extensive computer processing; the methods are being applied to many macromolecular assemblies.

PMID:
16443818
DOI:
10.1152/physiol.00045.2005
[Indexed for MEDLINE]
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