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Bioorg Med Chem Lett. 2006 Feb;16(3):668-71. Epub 2005 Nov 17.

Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Author information

1
Department of Chemistry, Yale University, New Haven, CT 06520-8107, USA.

Abstract

Following computational analyses, potential non-nucleoside inhibitors of HIV-1 reverse transcriptase have been pursued through synthesis and assaying for anti-viral activity. The general class Het-NH-Ph-U has been considered, where Het is an aromatic heterocycle and U is an unsaturated, hydrophobic group. Results for compounds with Het=2-thiazoyl and 2-pyrimidinyl are the focus of this report.

PMID:
16298131
DOI:
10.1016/j.bmcl.2005.10.037
[Indexed for MEDLINE]

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