Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17053-8. Epub 2005 Nov 8.

DCDC2 is associated with reading disability and modulates neuronal development in the brain.

Author information

1
Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520, USA.

Erratum in

  • Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18763.

Abstract

DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we identified a large polymorphic deletion that encodes tandem repeats of putative brain-related transcription factor binding sites in intron 2 of DCDC2. Alleles of this compound repeat are in significant disequilibrium with multiple reading traits. RT-PCR data show that DCDC2 localizes to the regions of the brain where fluent reading occurs, and RNA interference studies show that down-regulation alters neuronal migration. The statistical and functional studies are complementary and are consistent with the latest clinical imaging data for RD. Thus, we propose that DCDC2 is a candidate gene for RD.

PMID:
16278297
PMCID:
PMC1278934
DOI:
10.1073/pnas.0508591102
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center