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J Cell Biol. 2005 Nov 7;171(3):415-7.

Spying on IgE receptor signaling: simply complex, or not?

Author information

1
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA. derek.toomre@yale.edu

Abstract

Plasma membrane organization and the potential role, or not, of lipid raft microdomains in signal transduction is a controversial topic. Cross-correlation fluorescent correlation spectroscopy (CC-FCS) shows promise as a new approach to rapidly probe protein-protein interactions in living cells during signal transduction. CC-FCS data from studies of IgE receptor signaling challenge models of large stable lipid raft signaling domains and reveal a new complexity in the dynamic (re)organization of signaling complexes.

PMID:
16275748
PMCID:
PMC2171246
DOI:
10.1083/jcb.200510105
[Indexed for MEDLINE]
Free PMC Article

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