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Int J Pharm. 2005 Nov 23;305(1-2):180-5. Epub 2005 Oct 19.

Spray-freeze-dried liposomal ciprofloxacin powder for inhaled aerosol drug delivery.

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Department of Mechanical Engineering, University of Alberta, Aerosol Research Laboratory of Alberta, Edmonton, AB, Canada.


Spray-freeze drying was utilized to manufacture a liposomal powder formulation containing ciprofloxacin as a model active component. The powder forms liposomally encapsulated ciprofloxacin when wetted. Aerosol properties of this formulation were assessed using a new passive inhaler, in which the powder was entrained at a flow rate of 60l/min. A mass median aerodynamic diameter (MMAD) of 2.8 microm was achieved for this formulation. Using the experimental dispersion testing data, ciprofloxacin concentration in the airway surface liquid (ASL) was calculated using a Lagrangian deposition model. The reconstitution of the powder in various aqueous media gave drug encapsulation efficiencies as follows: 50% in water, 93.5% in isotonic saline, 80% in bovine mucin, 75% in porcine mucus and 73% in five-fold-diluted ex vivo human cystic fibrosis patient sputum.

[Indexed for MEDLINE]

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