Format

Send to

Choose Destination
Cancer Causes Control. 2005 Nov;16(9):1075-83.

Maternal pregnancy loss, birth characteristics, and childhood leukemia (United States).

Author information

1
Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St., New Haven, CT 06520-8034, USA. xiaomei.ma@yale.edu

Abstract

OBJECTIVE:

The authors evaluated the relation between maternal pregnancy loss, birth characteristics, and childhood leukemia in the Northern California Childhood Leukemia Study.

METHODS:

Incident cases of childhood leukemia (age 0-14 years) were rapidly ascertained, and controls were randomly selected from birth records and individually matched to cases. A total of 366 cases [313 acute lymphoblastic leukemia (ALL) and 53 acute myeloid leukemia (AML)] and 460 controls were included in this analysis. The biological mothers of all subjects provided detailed reproductive history and birth characteristics of the index children during a personal interview. Odds ratio (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Data on maternal pregnancy loss and birth characteristics were also available from the birth certificates of 96.3% of all subjects.

RESULTS:

History of miscarriage was associated with a significantly increased risk of AML (OR = 2.94, 95% CI: 1.03, 8.34), but not ALL. Neither birth weight, birth order, or parental ages appeared to be an important predictor of the risk of ALL or AML. A comparison between data from two different sources (interview versus birth certificate) indicated good reproducibility and offered some evidence against recall bias.

CONCLUSION:

Maternal history of miscarriage is associated with an increased risk of childhood AML.

PMID:
16184473
DOI:
10.1007/s10552-005-0356-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center