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J Pediatr. 2005 Sep;147(3):306-11.

Newborn screening for cystic fibrosis is associated with reduced treatment intensity.

Author information

1
United Kingdom Cystic Fibrosis Database, Division of Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.

Abstract

OBJECTIVES:

To determine whether the improved clinical status after newborn screening (NBS) for cystic fibrosis (CF) segregates with increased therapeutic intervention compared with presentation by clinical diagnosis (CD).

STUDY DESIGN:

In 2002, two populations (1 to 9 years of age) who presented (excluding meconium ileus) by NBS < or = 3 months of age or by CD were compared in an observational, cross-sectional design. NBS and CD populations (184 and 950 patients, respectively) were divided into 3-year age groups (1 to 3, 4 to 6, and 7 to 9 years). Therapies of duration >3 months were compared together with Pseudomonas aeruginosa infection status.

RESULTS:

NBS patients < or = 6 years of age received significantly fewer and less demanding therapies not explained by age, genotype, geography, or social deprivation. In 7- to 9-year-olds, significantly fewer NBS patients received intravenous antibiotics. NBS patients without P aeruginosa infection received significantly fewer therapies, but no differences were found between intermittently or chronically infected NBS and CD populations. Comparable results were found in deltaF508/deltaF508 subpopulations.

CONCLUSIONS:

CF populations diagnosed by NBS are associated with reduced treatment compared with age- and genotype-matched CD control subjects.

PMID:
16182666
DOI:
10.1016/j.jpeds.2005.05.034
[Indexed for MEDLINE]
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