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Bioconjug Chem. 2005 Jul-Aug;16(4):864-72.

Nucleic acid complexing glycosyl nucleoside-based amphiphile.

Author information

1
Faculté des sciences d'Avignon, 33 rue Louis Pasteur, F-84000 Avignon, France.

Abstract

A neutral amphiphile derived from uridine featuring two oleyl chains and one glucose for DNA binding was prepared using a convenient four-step synthetic route. The nucleic acid binding capabilities of this amphiphile were investigated by UV-vis, quasi-elastic light scattering (QELS), transmission electronic microscopy (TEM), gel electrophoresis, 31P NMR, IR, and circular dichroism (CD). Amphiphile-nucleic acid complex formation is a consequence of the amphiphilic character of the molecule, phosphate-sugar, and nucleobase-nucleobase interactions. This work presents for the first time a glyco-nucleo-amphiphile capable of binding efficiently the nucleic acid double helix structure.

PMID:
16029028
DOI:
10.1021/bc050029y
[Indexed for MEDLINE]

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