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Magn Reson Med. 1992 May;25(1):204-10.

Localized 13C NMR spectroscopy of myo-inositol in the human brain in vivo.

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Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut.


Natural abundance 13C NMR spectra obtained from 144-cm3 volumes in the human brain contained well-resolved resonances of myo-inositol after 60 min of data accumulation. A mean concentration of 7.2 +/- 0.5 mumol/g (+/- SE, n = 7) was calculated from the comparison with phantoms. 13C NMR spectroscopy thus provides a complementary role in the quantitation of metabolites also observed in the crowded 1H spectrum.

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