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Genes Dev. 2005 May 1;19(9):1013-21.

Neural guidance molecules regulate vascular remodeling and vessel navigation.

Author information

1
Institut National de la Santé et de la Recherche Médicale U36, Collège de France, 75005 Paris, France. anne.eichmann@college-de-france.fr

Abstract

The development of the embryonic blood vascular and lymphatic systems requires the coordinated action of several transcription factors and growth factors that target endothelial and periendothelial cells. However, according to recent studies, the precise "wiring" of the vascular system does not occur without an ordered series of guidance decisions involving several molecules initially discovered for axons in the nervous system, including ephrins, netrins, slits, and semaphorins. Here, we summarize the new advances in our understanding of the roles of these axonal pathfinding molecules in vascular remodeling and vessel guidance, indicating that neuronal axons and vessel sprouts use common molecular mechanisms for navigation in the body.

PMID:
15879551
DOI:
10.1101/gad.1305405
[Indexed for MEDLINE]
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