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J Exp Med. 2005 Feb 7;201(3):321-3.

Bacterial toxins and the immune system: show me the in vivo targets.

Author information

1
Yale University School of Medicine, New Haven, CT 06536, USA. jorge.galan@yale.edu

Abstract

Microorganisms that cause persistent infection often exhibit specific adaptations that allow them to avoid the adaptive immune response. Recently, several bacterial toxins have been shown in vitro to disrupt immune cell functions. However, it remains to be established whether these activities are relevant during infection and whether these toxins have specifically evolved to disrupt the adaptive immune system.

PMID:
15699067
PMCID:
PMC2213035
DOI:
10.1084/jem.20050080
[Indexed for MEDLINE]
Free PMC Article

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