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CMAJ. 2005 Feb 1;172(3):367-79.

Liver enzyme alteration: a guide for clinicians.

Author information

1
Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy. egiannini@unige.it

Abstract

Isolated alterations of biochemical markers of liver damage in a seemingly healthy patient can present a challenge for the clinician. In this review we provide a guide to interpreting alterations to liver enzyme levels. The functional anatomy of the liver and pathophysiology of liver enzyme alteration are briefly reviewed. Using a schematic approach that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, we review abnormal enzymatic activity within the 2 subgroups, the most common causes of enzyme alteration and suggested initial investigations.

PMID:
15684121
PMCID:
PMC545762
DOI:
10.1503/cmaj.1040752
[Indexed for MEDLINE]
Free PMC Article

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