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Ear Nose Throat J. 2004 Oct;83(10):692, 694-5.

Fluconazole nasal spray in the treatment of allergic fungal sinusitis: a pilot study.

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Department of Otolaryngology, Head and Neck Surgery, New York Presbyterian Hospital of Columbia, USA.


The authors describe a prospective pilot study designed to investigate the use of topical nasal antifungal spray in addition to systemic steroids and itraconazole in the treatment of allergic fungal sinusitis. Sixteen patients with a history of allergic fungal sinusitis were given fluconazole nasal spray and followed for 3 months. Stabilization or improvement of disease without significant side effects was observed in 12 of the 16 patients who were treated with this protocol. These results indicate that topical fluconazole application may help patients with allergic fungal sinusitis; however, a larger multicenter study with longer patient follow-up is required to validate these initial findings.

[Indexed for MEDLINE]

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