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Cell. 2004 Nov 24;119(5):579-81.

Chaperoned protein disaggregation--the ClpB ring uses its central channel.

Author information

1
Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, New Haven, CT 06536 USA.

Abstract

In this issue of Cell, exploit a clever manipulation of the Hsp100 ring chaperone, ClpB, to gain some mechanistic and physiologic understanding of the action of this chaperone in mediating ATP-dependent disaggregation of protein aggregates that accumulate in the bacterial cytoplasm under severe heat shock conditions.

PMID:
15550237
DOI:
10.1016/j.cell.2004.11.018
[Indexed for MEDLINE]
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