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Bioorg Med Chem Lett. 2004 Dec 20;14(24):5975-8.

Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists.

Author information

1
Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Chemistry, 5 Research Parkway, Wallingford, CT, USA. guanglin.luo@bms.com

Abstract

4-Amino-N-arylpiperidines serve as effective bioisosteres for N-arylpiperazines in the series of dihydropyridine NPY1 receptor antagonists. These were prepared by a ZnCl2-mediated reductive amination reaction between elaborated primary amines, 2 or 5, and 4-arylpiperidones.

PMID:
15546711
DOI:
10.1016/j.bmcl.2004.10.005
[Indexed for MEDLINE]

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