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CNS Spectr. 2001 Dec;6(12):978-9, 992.

Lack of association of apolipoprotein E polymorphism in obsessive-compulsive disorder.

Author information

1
Department of Psychiatric Genetics, National Mexican Institute of Psychiatry, Mexico City, Mexico. nicolini_humberto@yahoo.com

Abstract

Obsessive-compulsive disorder (OCD) could be considered a neurodevelopmental disorder, from several lines of evidence. One of the most widely studied genes in these disorders is the apolipoprotein E gene, particularly allele 4. We analyzed for association among patients with OCD versus normal controls and cognitively impaired patients. There were no significant differences between OCD probands compared with population controls. However, the cognitively impaired group showed a higher frequency of allele apolipoprotein E gene compared with normal controls and patients with OCD.

PMID:
15311189
DOI:
10.1017/s1092852900001085

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