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J Allergy Clin Immunol. 2004 Jul;114(1):28-33.

Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis.

Author information

1
Unidad de Mastocytosis, Laboratorio K. Frank Austen, Hospital Ramón y Cajal, Madrid, Spain. lescribano.hrc@salud.madrid.org

Abstract

Mastocytosis may be associated with clonal nonmast cell lineage hematologic diseases, including myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia. Here we present a patient with the simultaneous diagnosis of mastocytosis and an acute myeloid leukemia, M2 subtype in the French-American-British classification, with t(8;21) carrying a population of immature mast cell precursors, and discuss this presentation in the context of a potential pathogenetic cellular link between this leukemia and mastocytosis.

PMID:
15241340
DOI:
10.1016/j.jaci.2004.02.042
[Indexed for MEDLINE]

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