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J Clin Invest. 2004 Mar;113(6):788-94.

Multiple sclerosis.

Author information

1
Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. dhafler@rics.bwh.harvard.edu

Abstract

Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.

PMID:
15067307
PMCID:
PMC362131
DOI:
10.1172/JCI21357
[Indexed for MEDLINE]
Free PMC Article
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