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Am J Transplant. 2015 Jun;15(6):1598-604. doi: 10.1111/ajt.13176. Epub 2015 Feb 23.

Early liver transplantation for patients with acute alcoholic hepatitis: public views and the effects on organ donation.

Author information

1
University of Kansas School of Medicine, Kansas City, KS.
2
Department of History and Philosophy of Medicine, University of Kansas Medical Center, Kansas City, KS.
3
Department of Preventive Medicine and Public Health, University of Kansas School of Medicine-Wichita, Wichita, KS.
4
Saint Luke's Transplant Specialists, Saint Luke's Health System, Kansas City, MO.

Abstract

Patients with severe acute alcoholic hepatitis may not survive to fulfill the standard 6 months of abstinence and counseling prior to transplantation. A prospective study demonstrated that early liver transplantation in such patients improved 2 year survival from 23% to 71% and only 3 of 26 patients returned to drinking after 1140 days; graft function was unaffected. Nonetheless, this treatment protocol may raise public concerns and affect organ donation rates. A total of 503 participants took a survey made available at an online crowdsourcing marketplace. The survey measured attitudes on liver transplantation generally and early transplantation for this patient population, in addition to measuring responses to nine vignettes describing fictional candidates. The majority of respondents (81.5%, n = 410) was at least neutral toward early transplantation for these patients; only a minority (26.3%) indicated that transplantation in any vignette would make them hesitant to donate their organs. Middle-aged patients with good social support and financial stability were viewed most favorably (p < 0.001). Age was considered the most important selection factor and financial stability the least important factor (each p < 0.001). Results indicate early transplantation for carefully selected patients with acute alcoholic hepatitis may not be as controversial to the public as previously thought.

KEYWORDS:

alcoholism and substance abuse; clinical research/practice; ethics; ethics and public policy; liver disease; liver transplantation/hepatology; organ allocation; organ procurement and allocation; organ transplantation in general; survey

PMID:
25707427
DOI:
10.1111/ajt.13176
[Indexed for MEDLINE]
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