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Magn Reson Med. 1992 Sep;27(1):183-8.

Detection and assignment of the glucose signal in 1H NMR difference spectra of the human brain.

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Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510.


The difference between 1H NMR spectra obtained during eu- and hyperglycemia exhibited well-resolved glucose peaks between 3 and 4 ppm as demonstrated by comparison with solution spectra. Estimated increases were consistent with recent 13C NMR quantitations of intracerebral glucose. Difference spectra were measured in 36-ml volumes from the human brain every 3 min.

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