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Sci Total Environ. 2018 Feb 1;613-614:1349-1352. doi: 10.1016/j.scitotenv.2017.09.244. Epub 2017 Sep 28.

Urinary phthalate metabolite concentrations in relation to levels of circulating matrix metalloproteinases in pregnant women.

Author information

1
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
2
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
3
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
4
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA. Electronic address: meekerj@umich.edu.

Abstract

Phthalate exposure has been shown to be associated with adverse pregnancy outcomes. However, human studies informing relevant mechanistic pathways are lacking. Experimental studies have reported that matrix metalloproteinases (MMPs), which are responsible for extracellular protein degradation, may be upregulated in response to phthalate exposure. In this exploratory study we measured urinary phthalate metabolite concentrations, plasma MMP levels, and relevant covariates among 134 pregnant women. There were statistically significant or suggestive positive relationships between several phthalates, particularly between metabolites of di-(2-ethylhexyl) phthalate, with MMP-1 and MMP-9 levels. Further research is needed to confirm these results and how they may inform the mechanisms involved between phthalate exposure and adverse pregnancy outcomes.

KEYWORDS:

Biomarker; Environment; Enzyme; Epidemiology; Exposure; Pregnancy

PMID:
28968947
PMCID:
PMC5681360
DOI:
10.1016/j.scitotenv.2017.09.244
[Indexed for MEDLINE]
Free PMC Article

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