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J Endovasc Ther. 2003 Jun;10(3):590-4.

Thrombolytic therapy in the setting of arterial line-induced ischemia.

Author information

1
Department of Radiology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA. jfg@jhmi.edu

Abstract

PURPOSE:

To evaluate the use of percutaneous transcatheter thrombolysis in the treatment of thrombosis due to radial artery cannulation.

METHODS AND RESULTS:

Seven patients (4 women; age range 41-62 years) with symptomatic cannulation-induced thrombosis and failure to improve after systemic anticoagulation underwent 8 catheter-directed thrombolytic infusions at our institution over a 3-year period. Access was either antegrade through the brachial artery or retrograde through the femoral artery. Thrombolytic infusions with urokinase began 2 to 12 days (average 6) after removal of the radial artery catheter. The thrombolytic infusion was successful in 5 of 7 patients based on angiographic flow restoration with <20% residual thrombus and significant clinical improvement in the ischemia.

CONCLUSIONS:

When systemic anticoagulation has failed, percutaneous catheter-directed thrombolytic infusion appears to be effective in the treatment of most patients with severe ischemic hand symptoms due to thrombosis after radial artery cannulation.

PMID:
12932173
DOI:
10.1177/152660280301000327
[Indexed for MEDLINE]
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