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Cancer Genet Cytogenet. 2002 Nov;139(1):9-13.

Hematologic malignancies and Klinefelter syndrome. a chance association?

Author information

1
Section of Hematology-Oncology, Comprehensive Cancer Center of Wake Forest University, Medical Center Boulevard, Winston-Salem, NC 27157-1082, USA. ykeung@wfubmc.edu

Abstract

Klinefelter syndrome was first described in 1942 as an endocrine disorder characterized by gynecomastia, hypogonadism, small testes, and elevated levels of follicle-stimulating hormone. An extra X chromosome (i.e., 47,XXY) was subsequently demonstrated in these patients and an increased incidence of leukemia and lymphoma has been described. We report a retrospective study of a series of unselected patients with Klinefelter syndrome diagnosed by cytogenetic studies and the occurrence of hematologic malignancies. The literature is also reviewed.

PMID:
12547150
DOI:
10.1016/s0165-4608(02)00626-x
[Indexed for MEDLINE]

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